Download Advances in Drug Delivery Systems, 6. Proceedings of the by James M. Anderson PDF

By James M. Anderson

The forefront technology offered at this symposium represents the easiest of foreign pharmaceutics, polymer technological know-how, biotechnology, molecular biology and phone biology learn efforts. The ebook emphasises the subsequent components of drug supply examine: greater equipment of healing management, in particular for proteins and peptides; novel supply platforms; complex service and focusing on platforms; and new healing suggestions and provider, receptor and mobile interactions and mechanisms for healing purposes

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Read Online or Download Advances in Drug Delivery Systems, 6. Proceedings of the Sixth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 21–24, 1993 PDF

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Additional info for Advances in Drug Delivery Systems, 6. Proceedings of the Sixth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 21–24, 1993

Example text

Below, we consider the action of respecrin during its interaction with the cell surface antigen and the antigen secreted by the cell. The latter case is most unfavourable for regular immunotoxin application, since interaction with secretory antigens leads to neutralization of immunotoxins and a decrease in their efficiency. On the contrary, in the case of respecrin, there was essential difference between membrane-bound and secretory antigens, because interaction of the former with the target led to release of the bio­ logically active component, whose action was mediated by its receptor, and not by the target.

Y. Xu, Y. Matsumoto, T. Sugano, Y. M. Mitchell, E. Hersh and S. Zolla-Parner, Human mono­ clonal antibodies of the human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein gp41 en­ hance HIV-1 infection in vitro, Proc. Natl. Acad. Sei. USA, 87 (1990)3185-3189. 24 B. Mandel, Interaction of viruses with neutralizing an­ tibodies In: H. R. ) Comprehensive Virology, Plenum Press, New York, 1979, Vol. 15, pp. 37-121. J. Dimmock, Mechanisms of neutralization of ani­ mal viruses, J. Gen.

In contrast to immunotoxins, whose action is realized as a result of di- TABLE 4 Effect of SEA-containing respecrin on T-cell proliferation in the presence of B-cells or monocytes or in the absence of ac­ cessory cells (from Ref. [2]) Experimental conditions* [ 3H ] Thymidine incorporation (cpm) Without accessory cells In presence of monocytes In presence of B-cells 3000 5000 16000 aThe respecrin is obtained by mixing the SEA-IgG conjugate with 10-fold molar excess of antibodies to IgG. The accessory cells are preincubated with the respecrin for 1 h, thoroughly washed and then added to isolated T-cells.

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