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By James N. Pitts, etc.

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It was postulated that Bcl-2 Control Transfected Figure 5. Western blot analysis of actin, Bcl-2, and Bax in control cells and in cells directly after PDT was carried out at 10°C. MCFlOA cells, either transfected with Bcl-2 or not, were photosensitized with AlPc and then irradiated with a light dose of 100 mJcm-*. Reprinted with permission from Kim et al. [130] MECHANISMS OF PHOTODYNAMIC THERAPY 3s might be preferentially damaged by PDT thereby increasing the Bax:Bcl-2 ratio which subsequently leads to enhanced apoptosis.

1 Introduction ................................................................................................. 2 Photodynamic therapy: light. photosensitizer and oxygen .......................... 1 Light .................................................................................................. 2 Photosensitizers ................................................................................. 3 Oxygen ..............................................................................................

42. L. J. M. Olsen (1964). Further evaluation of the use of haematoporphyrin derivative as a new aid for the endoscopic detection of malignant disease. Dis. , 46, 676-679. 43. L. H. J. Baldes (1964). Haematoporphyrin derivative for the detection of cervical cancer. Obstet. , 24, 78. 44. L. J. J. Gray (1967). Hematoporphyrin derivative for detection and management of cancer. Cancer, 20,2255-2257. 45. S. Schwartz, K. Absolon, H. Vermund (1955). Some relationship of porphyrins, X-rays and tumors. Univ.

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