Download Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia by Andrew Hadley, Peter Soothill PDF

By Andrew Hadley, Peter Soothill

The powerful prevention, prognosis, and administration of alloimmune cytopenias has develop into a group attempt concerning hematologists, obstetricians, pediatricians, immunologists, laboratory technicians, midwives, and study scientists. This e-book has been written via specialists of their respective fields to collect the problems of pathogenesis, epidemiology, prevention, analysis, and medical administration. This complete yet obtainable account is broadly cross-referenced to stress the hyperlinks among pathogenesis and scientific sequels, among epidemiology and the reason for screening courses, and among analysis and healing intervention.

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Extra info for Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn

Sample text

69 Murphy FJ & Reen DJ (1996). Differential expression of function-related antigens on newborn and adult monocyte subpopulations. Immunology, 89, 587–91. 70 Warmerdam PAM, van der Winkel JGJ, Gosselin EJ & Capel PJA (1990). Molecular basis for a polymorphism of human Fc␥RII (CD32). Journal of Experimental Medicine, 172, 19–25. 71 Denomme G, Ryan G & Fernandes B (1997). The Fc␥RIIa-His131 allotype is overexpressed in infants with ABO hemolytic disease of the newborn. Blood, 90, 472–3a. 72 Ravetch JV & Perussia B (1989).

Effect of the binding of anti-Zwa antibodies on platelet function. Vox Sanguinis, 47, 280–9. 96 Beadling WV, Herman JH, Stuart MJ, Keashen-Schnell M & Miller JL (1995). Fetal bleeding in neonatal alloimmune thrombocytopenia mediated by anti-PlA1 is not associated with inhibition of fibrinogen binding to platelet GPIIb/IIIa. American Journal of Clinical Pathology, 103, 636–41. 97 Blaschke J, Goeken NE, Thompson JS, Dick FR & Gingrich RD (1979). Acquired agranulocytosis with granulocyte-specific cytotoxic autoantibody.

3 The immune destruction of fetal platelets The cellular interactions involved in the alloimmune destruction of platelets in the fetus are less well studied than those involved in red cell destruction. However, studies into autoimmune thrombocytopenia in adults suggest that the mechanism of platelet destruction is analogous to that of red cell destruction in HDFN. 80 This suggests that the fetal spleen may be the primary site of platelet destruction in alloimmune thrombocytopenia. 81,82 Data on the role of Fc␥ receptors come from both in vivo and in vitro studies.

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