By Andrew Hadley, Peter Soothill
The powerful prevention, prognosis, and administration of alloimmune cytopenias has develop into a group attempt concerning hematologists, obstetricians, pediatricians, immunologists, laboratory technicians, midwives, and study scientists. This e-book has been written via specialists of their respective fields to collect the problems of pathogenesis, epidemiology, prevention, analysis, and medical administration. This complete yet obtainable account is broadly cross-referenced to stress the hyperlinks among pathogenesis and scientific sequels, among epidemiology and the reason for screening courses, and among analysis and healing intervention.
Read Online or Download Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn PDF
Similar hematology books
McMaster Univ. , Hamilton, Canada. Summarizes the prior 25 years of study within the box. issues: HIT will be thought of a clinicopathologic syndrome, the significance of antibody-mediated activation of platelets and endothelium, and the inconstant nature of HIT: its variable frequency and medical presentation.
It is a accomplished haematology textual content e-book. Very worthy for medical and Lab haematologists, trainees and lab scientists
By means of featuring the newest technological advances and transforming into nationwide and foreign law, this new booklet explores state of the art advancements within the demanding box of tissue and telephone processing. It offers a consultant to more straightforward and more secure perform in operational ideas of renovation, decontamination, and sterilization.
This e-book describes the most recent tools in oncological and hematological diagnostics, together with immunological, molecular genetic and cytogenetic assays. All equipment are defined of their varied adaptations and in comparison when it comes to rate and effectiveness. each one bankruptcy ends with an in depth "how-to-do" part.
- Atlas of Clinical Hematology
- Lymphatic Mapping and Probe Applications in Oncology
- The Principles of Clinical Cytogenetics
- Advances in Immunology
- Coagulation and Flocculation, Second Edition (Surfactant Science)
Extra info for Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn
69 Murphy FJ & Reen DJ (1996). Diﬀerential expression of function-related antigens on newborn and adult monocyte subpopulations. Immunology, 89, 587–91. 70 Warmerdam PAM, van der Winkel JGJ, Gosselin EJ & Capel PJA (1990). Molecular basis for a polymorphism of human Fc␥RII (CD32). Journal of Experimental Medicine, 172, 19–25. 71 Denomme G, Ryan G & Fernandes B (1997). The Fc␥RIIa-His131 allotype is overexpressed in infants with ABO hemolytic disease of the newborn. Blood, 90, 472–3a. 72 Ravetch JV & Perussia B (1989).
Eﬀect of the binding of anti-Zwa antibodies on platelet function. Vox Sanguinis, 47, 280–9. 96 Beadling WV, Herman JH, Stuart MJ, Keashen-Schnell M & Miller JL (1995). Fetal bleeding in neonatal alloimmune thrombocytopenia mediated by anti-PlA1 is not associated with inhibition of ﬁbrinogen binding to platelet GPIIb/IIIa. American Journal of Clinical Pathology, 103, 636–41. 97 Blaschke J, Goeken NE, Thompson JS, Dick FR & Gingrich RD (1979). Acquired agranulocytosis with granulocyte-speciﬁc cytotoxic autoantibody.
3 The immune destruction of fetal platelets The cellular interactions involved in the alloimmune destruction of platelets in the fetus are less well studied than those involved in red cell destruction. However, studies into autoimmune thrombocytopenia in adults suggest that the mechanism of platelet destruction is analogous to that of red cell destruction in HDFN. 80 This suggests that the fetal spleen may be the primary site of platelet destruction in alloimmune thrombocytopenia. 81,82 Data on the role of Fc␥ receptors come from both in vivo and in vitro studies.